| Description |
1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Note |
Includes index. |
| Contents |
Intro -- Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters: Concepts, Methods, a ... -- Copyright -- Contents -- Contributors -- Foreword -- References -- Preface -- Part I: Techniques for identifying and quantifying drugs and metabolites -- Chapter 1: Bioanalysis of small and large molecule drugs, metabolites, and biomarkers by LC-MS -- 1. Introduction -- 2. Complexity of contemporary bioanalysis -- 3. Bioanalytical requirements for supporting discovery, nonclinical, and clinical studies -- 4. Current regulatory landscape for bioanalysis |
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5. General considerations for bioanalysis for sample collection -- 6. Diagnosis and mitigation of nonspecific adsorption loss for urine bioanalysis -- 7. Tissue bioanalysis -- 8. Managing unstable metabolites such as acyl glucuronide -- 9. General considerations for bioanalysis for extraction, chromatography, and MS detection -- 10. Selected applications for LC-MS bioanalysis -- 10.1. LC-MS of large molecules -- 10.1.1. LC-MS bioanalysis of mAb -- 10.1.2. LC-MS bioanalysis of ADC -- 10.1.3. LC-MS bioanalysis of PDC -- 10.1.4. LC-MS bioanalysis of protein biomarkers |
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10.3.3. Fatty acid amide hydrolase biomarkers (authentic matrix and surrogate analytes) -- 10.4. LC-MS analysis of metabolites and MIST -- 10.4.1. Metabolite quantitation strategy -- 10.4.2. LC-MS bioanalysis of polar metabolites -- 10.4.3. Bioanalysis of chiral compounds -- 10.4.4. Unexpected assay challenge during analysis of patient samples -- 11. Conclusion and future perspective -- References -- Chapter 2: Recent advances in mass spectrometric and other analytical techniques for the identification of drug metabolites -- 1. Introduction -- 2. Sample preparation strategies |
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2.1. Solid-phase extraction -- 2.2. Supported phase liquid extraction -- 2.3. Liquid-liquid extraction -- 2.4. Protein precipitation -- 3. Optical detectors and chromatographic separation techniques -- 3.1. Ultra-performance liquid chromatography -- 3.2. Supercritical fluid chromatography -- 4. Different types of Ionization techniques and mass spectrometric scan functions -- 4.1. Ionization techniques -- 4.2. Mass analyzers and different acquisition modes -- 4.3. Inductively coupled mass spectrometry (ICP-MS) -- 5. Wet chemistry techniques combined with MS |
| Subject |
Drugs -- Analysis.
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Drugs -- Metabolism.
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Metabolites.
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Biochemical markers.
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Pharmaceutical Preparations -- analysis |
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Pharmaceutical Preparations -- metabolism |
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Biomarkers |
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Médicaments -- Analyse.
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Médicaments -- Métabolisme.
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Métabolites.
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Marqueurs biologiques.
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Biochemical markers
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Drugs -- Analysis
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Drugs -- Metabolism
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Metabolites
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| Added Author |
Ma, Shuguang.
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Chowdhury, Swapan K.
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| Other Form: |
Print version: Identification and quantification of drugs, metabolites, drug metabolizing. Amsterdam : Elsevier, 2020 0128200189 9780128200186 (OCoLC)1130251159 |
| ISBN |
9780128200193 (electronic bk.) |
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0128200197 (electronic bk.) |
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0128200189 |
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9780128200186 |
| Standard No. |
AU@ 000067628761 |
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AU@ 000068659044 |
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